The next decade will see the emergence of new multi-wavelength All-Sky Surveys, such as Rubin/LSST, Sphere-X, WFIRST, EUCLID, and PFS that are poised to revolutionize a broad range of astrophysical topics. The DSA-2000 radio camera, commencing construction in 2024, will provide a sensitive all-sky radio component to these surveys. It will consist of 2,000 x 5-m dishes operating between 0.7-2 GHz and will operate as a radio camera, providing the community with uniquely accessible images and data cubes rather than visibility data products. The DSA-2000 images will have few-arcsecond resolution, sub-microJansky sensitivity, and dynamic ranges >100,000 across the entire sky. Through a sixteen-epoch all-sky survey, the DSA-2000 will map, catalog, characterize and monitor over a billion radio sources with full polarization, with detailed HI observations to z=1. We will discuss frontier topics that this new generation of surveys will provide, including unprecedented observations of the static sky of nearby and distant galaxies, as well as the transient sky. The DSA-2000 will be a leading instrument for multi-messenger astronomy through the discovery and characterization of the electromagnetic counterparts to gravitational wave (GW) sources detected by LIGO-Virgo-KAGRA and by timing a suite of millisecond pulsars to enable the first detections of nanoHertz GWs from individual binary supermassive black holes (SMBHs) in galaxy mergers. In addition, time-domain analyses of DSA-2000 survey data, including commensal searches for FRBs and pulsars, will deliver transformational samples of events that populate the dynamic radio sky.